The WHO Public Health laboratories knowledge sharing platform was launched in May 2020 to support COVID-19 reference laboratories facing challenges such as: establishing and transferring SARS-CoV-2 testing protocols, facing reagent shortages and managing the decentralization of testing.The initiative quickly expanded to include a global audience of laboratory stakeholders. The primary tool used for knowledge sharing is regular webinars, the organization of which is coordinated by the WHO Public Health Laboratory Strengthening unit (Lyon office) together with WHO Regional Offices, with simultaneous interpretation in 6 languages (Arabic, English, French, Portuguese, Russian and Spanish). In 2022, followers of the webinar series have also benefitted from a broadened scope of practice, with sessions now being offered on other epidemic-prone diseases and health emergencies and cross-cutting laboratory topics.
Month: Apr 2023
Leveraging the research, collaborations and commercialisation successes in contributing to Singapore’s fight against the global COVID-19 pandemic, Duke-NUS Medical School today announced that it is working with the Bill and Melinda Gates Foundation to develop the Asia Pathogen Genomics Initiative (APGI) to contribute to regional pandemic preparedness by improving genomic surveillance. Duke-NUS also launched a new regional centre to strengthen regional research capacity, cooperation and preparedness for future pandemic and public health threats.
Called the Centre for Outbreak Preparedness (COP), it will collaborate with key public sector partners and research institutions, as well as overseas partners such as the Bill & Melinda Gates Foundation and the World Health Organization (WHO). COP will leverage Duke-NUS’ strong partnerships around the world, with particular focus on research institutes in South and Southeast Asia to increase the region’s research capacity and capabilities.
Using the platform of the first FIFA Arab Cup™, the World Health Organization (WHO), FIFA and the Qatari authorities are launching the #ACTogether campaign to call for teamwork and unity to ensure equitable access to COVID-19 vaccines, treatments and tests.
A large proportion of the global population remains susceptible to infection and at an increased risk of severe disease and death. Vaccine inequity persists in many parts of the world; of the nearly 7.5 billion doses of COVID-19 vaccines administered globally by mid-November 2021, only 0.6% had been administered in low‑income countries. The WHO is emphasizing the need to scale up access to vaccines, treatments and diagnostics, through support to the global Access to COVID-19 Tools (ACT) Accelerator equity initiative, as well as the importance of strict adherence to public health measures.
FIFA will utilize football’s substantial platform during the FIFA Arab Cup Qatar 2021™ with a series of videos for broadcast, both in-stadium and around Doha. Team captains will also show their support for the message, while each participating member association will have assets to share with its fans via its social and digital platforms. The #ACTogether awareness initiative was first rolled out during the last edition of the FIFA Club World Cup™ in Qatar in February 2021 and its latest iteration stresses that the COVID-19 pandemic is not over.
A new assessment by the World Health Organization (WHO) shows that only 14.2% – or one in seven – COVID-19 infections are being detected in Africa. To reverse that trend and curb transmission, the WHO Regional Office for Africa today announced a new initiative to enhance community screening for COVID-19 in eight countries. The programme aims to reach more than 7 million people with rapid diagnostic tests in the next year.
The WHO analysis used the COVID-19 calculator developed by Resolve to Save Lives which estimates infections based on reported number of cases and deaths and an infection fatality rate grounded in population-based studies. It found that as of 10 October 2021 the cumulative number of COVID-19 infections is estimated to be 59 million in Africa, which is seven times more than the over 8 million cases reported.
The countries participating in the programme are Burundi, Cote d’Ivoire, Democratic Republic of the Congo, Guinea-Bissau, Mozambique, Republic of the Congo, Senegal and Zambia. To kick off implementation, WHO has disbursed US$ 1.8 million to the eight countries. WHO will support countries to interrupt disease transmission, through active case finding by deploying teams in local communities to seek out possible contacts of people who have tested positive for COVID-19 and offer antigen rapid diagnostic tests.
A new agreement reached by the Global Fund and several producers of COVID-19 antigen rapid diagnostic tests (Ag RDTs) has resulted in a significant drop in the price of these tests, potentially making the products more affordable for many governments of low- and middle-income countries.
This announcement from the Global Fund, co-convenors of the ACT-A Diagnostics Pillar alongside FIND, ensures that the COVID-19 diagnostics produced by these quality-assured suppliers will be available at game-changing prices ranging from US$1.00 to US$2.00 per test or less. These developments have the potential to shift the diagnostics market and make testing more accessible.
On this episode of the Global Health Matters podcast, FIND CEO Bill Rodriguez and Sikhulile Moyo, who led the team that helped discover the Omicron variant in Botswana, to discuss key questions such as “how available are essential diagnostics in low- and middle-income countries (LMICs)?” in an effort to understand the state of diagnostic testing in LMICs and how to achieve equity in access to testing in all countries.
Dr. Fifa Rahman, Prof Brook Baker, and Dr. Carolyn Gomes, ACT-A CSO Representatives for the Diagnostics and Therapeutics Pillars, have come together to author an op-ed on the need to accelerate testing equity for diagnostics and other COVID-19 tools.
At the time of writing, access to rapid diagnostic tests (RDTs) and self-tests for COVID-19 were widely accessible in the Global North, but access in the Global South was far more constrained. The authors urgently call upon global health actors within the ACT-Accelerator to take action, including calling on WHO to accelerate development of guidelines for self-testing.
Rapid diagnostic tests (RDTs) based on lateral flow assays have emerged as important diagnostic tools in the management of diseases such as malaria and COVID-19. However, errors can arise when individuals perform these tests and interpret their results. Mobile smartphone applications (apps) for reading RDTs offer a promising option to improve the accuracy of the interpretation of test results. This has been demonstrated with hardware RDT readers in low- and middle-income countries (LMICs). With apps, however, no additional hardware is needed, apart from a smartphone. Such smartphones are already becoming widely available, avoiding cost, supply chain, and maintenance concerns that would occur if new hardware needed to be deployed to read RDTs.
The aim of this report is to share a summary of publicly available information about mobile applications for reading RDTs. The focus is on RDT-reading apps that do not require additional hardware beyond a mobile device (meaning a smartphone or tablet) and the RDT kit. Apps for diseases of poverty and low-resource settings are of particular interest, but the report also includes other apps, to support an understanding of this industry overall.
Rapid diagnostic tests (RDTs) have played a critical role in the global COVID-19 response, as well as in the management and diagnosis of other diseases, such as malaria and HIV. However, without correct performance of the test and interpretation of the result, the utility of these tests may be compromised, presenting timely and accurate clinical assessment and disease surveillance.
This Target Product Profile lays out minimal and optimal characteristics for RDT readers to serve as companion tools to support improved test performance, interpretation, and reporting.
Rwanda has raised the bar in using digital tools to scale up community-based testing in its COVID-19 response.
A national Joint COVID Task Force, established in February 2020 before the first case was confirmed, led the pandemic response of this African country. The team gave both high-level strategic guidance and day-to-day operational support.
This had, however, been preceded by years of investment in the broader digital health infrastructure, where digital technologies were expanded to support service delivery – a longstanding government priority.
Institutions in Rwanda were therefore able to combine resources and capacities to respond to emerging problems. Adopting a multi-sectoral approach from the start has allowed rapid deployment of interventions and more efficient troubleshooting.
It also helped the country to build COVID-specific digital systems to strengthen the areas of testing, contact tracing, patient support and surveillance.
Rwanda’s numbers
First registered COVID-19 case: 14 March 2020
14 March 2021: more than 20 000 cases diagnosed, with mortality rate of 1.4%
Sharpest peak in cases: late 2020 and early 2021. This prompted stringent restrictions on movement that led to a rapid decline in new cases.
Testing the toolbox
Rwanda has used District Health Information Software (DHIS-2) to survey and monitor disease since 2011 and, in early 2020, this system was adapted to capture data on COVID-19 diagnosis and case management.
DHIS-2 is integrated with the laboratory information system which allows for automated transmission of data.
COVID-19 Command Posts, the sub-national operational centres of the Joint COVID Task Force, receive and analyse surveillance data from these different systems to inform policy and programme decisions.
Rwanda also devised a stringent port of entry system to avoid importing COVID-19 cases.
Other technologies were deployed in selected settings, including the internal Visitor Tracking Record and the e-ASCOV pilot, a locally developed application to help give access to rapid antigen testing.
Patient-facing tools
- WhatsApp help line
- Unstructured supplementary service data (USSD) platform, which provides basic information on COVID-19 on any phone with no data or airtime requirements
- WelTel app, where patients can report symptoms
- Standard electronic medical record (EMR) system
- Online results portal
- Open Data Kit (ODK) application which captures data for targeted surveillance activities outside of health facilities, particularly in hotspots.
Impact of digital tools
The use of digital tools in Rwanda has had a significant impact. For example, through integrating laboratory and health management information systems, the testing process is now paperless. All facilities capture data in the same central system.
Patient unique health codes (UHCs) also allow data transfer between different digital solutions. This cuts down the time taken by health care workers to record and report data, as it is captured in real-time at the point of care.
Application programming interfaces have also been developed for a number of tools to enable interoperability.
Mobile-data collection tools for community-based surveillance have generated valuable insights to inform timely responses to outbreaks.
Monitoring cases and contacts remotely using digital tools has reduced the burden on the health system. This has allowed the country to focus limited capacity on delivering services to the most at-risk individuals, while consistently monitoring other patients.
Key success factors in Rwanda
- Pre-existing digital infrastructure
- Political will, with digital infrastructure bolstered by political commitment at the highest levels of government
- National ownership of systems, minimising the challenge of isolated pilots, duplicate interventions and “data fog”
- Building on existing tools
- Multisectoral collaboration
- Providing patients with direct access to results.
Challenges
The lack of readiness of health care workers to adopt new digital tools can be a barrier to successful implementation.
This is worsened in a crisis such as COVID-19, where systems are already overwhelmed with new protocols and interventions.
Resource requirements are also unpredictable due to the rapidly evolving nature of the pandemic.
It is important to coordinate decisions on selection of digital tools from among numerous vendors.
KEY INSIGHTS
- Ensuring integration of national COVID-19 data (public and private sector) into one platform enhances understanding of the pandemic and simplifies data management.
- Leveraging databases in other areas can minimise the time and effort required for individual data capture.
- Digital tools, particularly on mobile devices, are key in providing decentralised testing services.
While Rwanda is still in the early stages of rolling out its approach, it shows potential to expand and standardise testing outside of health facilities.