This report provides information on cumulative achievements of the ACT-Accelerator partnership since the start of the pandemic to end September 2022, an account of the outcomes of the four Pillars’ work towards the milestones set out in the 2021-22 Strategic Plan, and incorporates the regular Q3 Update. Additionally, six Impact Stories demonstrate the real-world impact of the partnership in countries, focusing on areas such as expanding access to medical oxygen, accelerating vaccine delivery and rolling out test and treat pilots.